Description
Product Characteristics: For the quantitative determination of rat insulin-like growth factors 1 receptor (IGF-1R) concentrations in serum, plasma, tissue homogenates.
Target Information: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]